Patents are legal documents drawn up by inventors and lawyers and granted by various patent offices around the world, to protect the inventors' intellectual property. The short description accompanying each patent in this Patents section is therefore taken from the legal document as is, with minor corrections for Greek symbols and obvious spelling errors. The patents included in this section may be for material products (defensins or defensin-like peptides or nucleic acid sequences, synthetic or natural) or for novel methods of detecting, quantitating, synthesizing, or delivering antimicrobial peptides/nucleic acid sequences in general. The curators' criterion for inclusion in this section is broader for novel methods than for material products, in the hope that these methods may in future be similarly applied to defensins.

Patents in which the defensins or defensin-like material products and methods as above are not novel, such as biomarker sets containing unmodified defensin or defensin-like peptides or oligonucleotides, are excluded from this section. The exception to such exclusions is where the patent provides other novel defensin-related material products or methods in addition to those non-novel of the biomarker set itself. This exclusion is because the reasonable presence of defensin or defensin-like sequences or indeed any other sequences in patented biomarker sets is necessarily attributed to some prior discovery of disease state correlation with such sequences. The curators have observed therefore that the novel discovery in biomarker-related patents is often the method of biomarker array analysis and validation as well as its resultant implications for diagnostics and prognostics. The expert evaluation of such biomarker analysis and validation is well outside the scope of the Defensins Knowledgebase. The reader is respectfully referred to a biomarker database specific to the disease to perform his own assessment of the validity of the biomarker.

Methods not pertaining to the antimicrobial activity of defensins, but where defensins or antimicrobial peptides or small cationic peptides or disulphide-bonded peptides or their respective nucleic acid sequences are suggested in some unambiguous detail to play a useful role in the method, with or without supporting experimental evidence, are included as well in this section. Patents in which natural defensins are up/downregulated in a clearly defined signal transduction pathway as a result of the unrelated patented novel compound or method are also included. And lastly, all patents showing experimental work done with defensins or antimicrobial peptides or small cationic peptides or disulphide-bonded peptides or their respective nucleic acid sequences, where such peptides or nucleic acid sequences are not the experimental controls, are included without exception.

The data in this section have been extracted from the academic version of SciFinder Scholar 2007 and from public Google search - a wide range of defensin-related patents are included.


Results 21 - 30 of 333

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Last updated: 20th February 2008

Patent No.: WO 011612
Wound dressing comprising a water soluble polymer and a water soluble glass-encapsulated antimicrobial agent.
Applicant: David N, Fink D, Tranchemontagne A (2007)
Anti-microbial wound dressings, methods of making anti-microbial wound dressings and methods of treating wounds with an anti-microbial wound dressing are provided. The anti-microbial wound dressings can include a water-sol. film-forming polymeric carrier material and a water-sol. glass-encapsulated anti-microbial agent, which is embedded within the carrier and/or coated on a surface thereof. Addnl. active agents useful in wound care can also be embedded in and/or coated on a surface of the carrier and/or water-sol. glass.

Patent No.: WO 011363
Fusion antibodies comprising antigen binding domain, proteinase inhibition domain and dimerization domain for treating immune disease, infection, inflammation and cancer.
Applicant: Ledbetter JA, Hayden-Ledbetter MS, Thompson PA, Tan PH (2007)
The present invention relates to constructs and methods for the treatment of diseases, disorders and conditions, including those relating to or involving autoimmune disorders, inflammation, bacterial, fungal, and viral infections, and diseases caused by or involving uncontrolled or abnormal proliferation of cells, including cancer. The fusion proteins comprise antigen binding VH and/or VL domain, proteinase inhibitor domain (e.g. trappin, SLPI, WAP, TIMP, cystatin and defensin), as well as a dimerization domain (e.g. CH3, IgG1 hinge, etc.). The proteinase is selected from elastase, alpha1-proteinase, proteinase 3, chymotrypsin, trypsin, chymase, chymotryptic enzyme, human leukocyte elastase, cathepsin G, tryptase, pancreatic elastase, etc.

Patent No.: WO 007116
A secreted protein with sequence characteristics of a beta-defensin and the gene encoding and their uses.
Applicant: Yorke M, Power C, Bienkowska J, Michalovich D, White SJ (2007)
A protein, INSP139, that has sequence features that identify it as a secreted protein and as a member of the beta-defensin family is identified by sequence homol. The protein and the gene may be useful in the diagnosis, prevention, and treatment of disease (no data).

Patent No.: WO 006079
Multi-faceted approach for the management of plant pathogens.
Applicant: Heath RL, Anderson MA (2007)
The present invention relates generally to a multi-faceted approach to the control of plant pathogens including plant pests. More particularly, the present invention relates to plants such as crop plants genetically modified to produce at least two pesticidal or pestistatic agents which in at least one agent is a serine proteinase inhibitor or precursor thereof from the solanaceae family and at least one other is a non-serine proteinase inhibitor selected from the list a Bt protein, a member of the CRY family, a VIP and a defensin, and wherein said exhibits resistance or reduced susceptibility to a pest.

Patent No.: US 207209
Trophic factor combinations for treatment of nervous system injuries.
Applicant: Murphy CJ, McAnulty JF, Mitchell GS, Golder FJ (2007)
The present invention relates to a compn. including an effective amt. of at least one of an antimicrobial peptide and a substance having an antimicrobial peptide effect and an effective amt. of a neurotrophin. The compn. can also include an effective amt. of at least one of a growth factor and a neuropeptide. An injury to the nervous system of an animal can comprise applying to the injury an effective amt. of at least one antimicrobial peptide (e.g., BNP-1, also known as bactenecin) in compns. also including an effective amt. of one or more trophic factors selected from the group consisting of a growth factor (e.g., insulin-like growth factor 1) , a neurotrophin (e.g., bone-derived neurotrophin), and a neuropeptide (e.g., substance P) to the injury. Application of the above compns. has an effect select from the group consisting of reduced pain, neuronal plasticity, a neuroprotective effect, reduced body wt. loss, increased motor recovery, increased evoked potential amplitudes, and lowered threshold current.

Patent No.: US 122854
Method for diagnosing colon cancer by detecting defensin alpha6.
Applicant: Nam M-J (2007)
The present invention relates to a method for diagnosing colon cancer by detecting a colon cancer specific antigen, defensin .alpha.6 from the blood of patient and a diagnostic kit for colon cancer comprising anti-defensin .alpha.6 antibody, The diagnostic kit for colon cancer of present invention comprises, a solid support such as 96-well plate for ELISA, nitrocellulose membrane, polyvinylidene fluoride membrane, microplate, glass substrate, polystyrene substrate, silicone substrate or metalplate, on which anti-defensin .alpha.6 antibody is immobilized; and, a means for detecting colon cancer specific antigen such as a primary antibody which specifically binds with an antigen conjugated with an antibody on a solid substrate and a secondary antibody-signal complex which specifically binds with the primary antibody. The diagnostic kit of the invention can diagnose colon cancer with the minute amount of patients' blood, which makes possible the easy and simple diagnosis of colon cancer.

Patent No.: US 003538
Prevention of growth of microorganisms on medical devices.
Applicant: Madhyastha S (2007)
The present invention provides compns. for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt thereof. The invention further provides methods for prepg. medical devices with such compns. A study was carried out to assess the efficacy of silicone catheter coated with protamine sulfate in preventing E. coli infection of s.c. implanted segments of silicone catheters. All segments were completely free from bacterial colonization.

Patent No.: WO 097464
Recombinant expression of defensins in filamentous fungi.
Applicant: Kristensen H-H, Schnorr KM, Hansen MT (2006)
The present invention relates to recombinant expression of defensin antimicrobial peptides in fermentation of filamentous fungi.

Patent No.: WO 097110
Defensin family polypeptides having antimicrobial activity and polynucleotides encoding them from Arenicola marina.
Applicant: Spodsberg N, Schnorr KM (2006)
Fourteen polynucleotides encoding polypeptides having antimicrobial activity were discovered by signal trapping of an Arenicola marina cDNA library. HMM (hidden Markov model) profiles from the PFAM database were used to identify these antimicrobial polypeptides as members of the defensin protein family, and they were designated marinasins. The cDNAs encoding mature marinasins were amplified from the A. marina gut cDNA library and fused to a DNA fragment encoding the Plectasin pre-pro region for expression in Aspergillus oryzae. Antimicrobial activity was detected by radial diffusion assays. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using polypeptides.

Patent No.: WO 084463
Systemic treatment of infections with defensins.
Applicant: Kristensen H-H, Mygind PH, Segura DR (2006)
The invention relates to methods for treating systemic microbial infections with defensin antimicrobial peptides. The invention also relates to a medicament and a method for prepg. a medicament.