Protein : Cryptdin 1
Description : Defensin, alpha 1
Defensin-related cryptdin peptide
Defensin related cryptin peptide 1
Cryptdins (enteric defensin) are homologs of myeloid defensins (antimicrobial peptide components of phagocytic leucocytes) and have an extended N termini as compared to the myeloid defensins.
Family : Vertebrate Alpha
Organism : Mus musculus (Mouse)
Alias
Defcr
Defcr1
Defa1
Other Databases
NCBI: 13216
SwissProt: P11477
MGI: 94880
Expression
Sites of Expression : Paneth cells [Granulated secretory epithelial cells found in the small intestine] release cryptdins into the lumen of the crypts of Lieberk├╝hn.
Sequence Information
Description:Defensin-related cryptdin peptide precursor
Sequence Length:93 aa
Protein Sequence:MKKLVLLFAL VLLGFQVQAD SIQNTDEETK TEEQPGEEDQ AVSVSFGDPE GTSLQEESLR DLVCYCRSRG CKGRERMNGT CRKGHLLYTL CCR
Molecular Weight:10461 Da
Sequence Organization:Signal peptide: 1-19
Proprotein: 20-58
Mature peptide: 59-93
Organisation of Gene
Chromosome Location:8
Description:Characterization of genomic and cDNA clones of cryptdins revealed that each of the genes had a two-exon structure instead of the three-exon structure of the myeloid defensin family.
Structure Information
Mature peptide Sequence:LR DLVCYCRSRG CKGRERMNGT CRKGHLLYTL CCR
Mature Sequence Length:35 aa
No. of disulfide bonds:3
Disulfide Connectivities:64-92, 66-81, 71-91
Antimicrobial Activity
Microbe Type Microbe Name Antimicrobial Activity
Gram-negative bacteriaEscherichia coliCryptdins 1,3 and 6 had similar activities and were three to five-fold more active than cryptin 2.
Literature
(1) Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME. Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect. Immun. 1994 Nov;62 (11):5040-7 [PMID: 7927786]
 
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