Protein : Cryptdin 15
Description : Defensin-related cryptdin 15
Cryptdins (enteric defensin) are homologs of myeloid defensins (antimicrobial peptide components of phagocytic leucocytes) and have an extended N termini as compared to the myeloid defensins.
Family : Vertebrate Alpha
Organism : Mus musculus (Mouse)
Alias
Defcr15
Other Databases
NCBI: 13234
SwissProt: P50713
MGI: 99586
Expression
Sites of Expression : Paneth cells [Granulated secretory epithelial cells found in the small intestine] release cryptdins into the lumen of the crypts of Lieberk├╝hn.
Sequence Information
Description:Defensin-related cryptdin 15 precursor
Sequence Length:93 aa
Protein Sequence:MKTLVLLSAL VLLAFQVQAD PIQNTDEETK TEEQPGEDDQ AVSVSFGDPE GSSLQEESLR DLVCYCRKRG CKRREHINGT CRKGHLLYML CCR
Molecular Weight:10503 Da
Sequence Organization:Signal peptide: 1-19
Proprotein: 20-58
Mature peptide: 59-93
Organisation of Gene
Chromosome Location:8
Description:Characterization of genomic and cDNA clones of cryptdins revealed that each of the genes had a two-exon structure instead of the three-exon structure of the myeloid defensin family.
Structure Information
Mature peptide Sequence:LR DLVCYCRKRG CKRREHINGT CRKGHLLYML CCR
Mature Sequence Length:35 aa
No. of disulfide bonds:3
Disulfide Connectivities:64-92, 66-81, 71-91
 
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